+ 44 (0) 7725112986




-Rodriguez-Hernandez I, Maiques O, Cantelli G, Perdrix A, Monger J, Fanshawe B, Karagiannis S, Santacana M, Mathias Guiu X, Maria Marti R, Orgaz JL, Fruhwirth G, Malanchi I, Sanz-Moreno V (2020) WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
Nature Communications. https://doi.org/10.1038/s41467-020-18951-2

-Farrugia AJ, Rodríguez J, Orgaz JL, Lucas M, Sanz-Moreno V, Calvo F. Cdc42EP5/BORG3 coordinates septin and actin networks to promote actomyosin function and melanoma invasion and metastasis (2020)
Journal Cell Biology. https://doi.org/10.1083/jcb.201912159

-McLeod R, Kumar R, Papadatos-Pastos D, Mateo J, Brown JS, Ingles Garces AH, Ruddle R, Decordova S, Jueliger S, Ferraldeschi R, Maiques O, Sanz-Moreno V, Jones P, Traub S, Halbert G, Mellor S, Swales KE, Raynaud FI, Garrett MD and Banerji U. First-in-human study of AT13148, a dual ROCK-AKT inhibitor in patients with solid tumors.
Clinical Cancer Research. https://doi.org/10.1158/1078-0432

-Wong PP, Muñoz-Félix JM, Hijazi M, Kim H, Robinson S, de Luxan-Delgado B, Rodriguez-Hernandez I, Maiques O, Meng Y-M, Meng Q, Bodrug N, Dukinfield MS, Reynolds LE, Elia G, Clear A, Harwood C, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Matchett KP, Henderson NC, Szlosarek PW, Dreger SA, Smith S, Jones LJ, Gribben JG, Cutillas P, Meier P, Sanz-Moreno V and Hodivala-Dilke KM (2020) Cancer burden is controlled by mural cell-beta3-integrin regulated crosstalk with tumor cells
Cell, https://doi.org/10.1016/j.cell.2020.02.003

-Orgaz JL, Crosas-Molist E, Sadok A, Perdrix-Rosell A, Maiques O, Monger J, Rodriguez-Hernandez I, Mele S, Georgouli M, Bridgeman V, Karagiannis P, Pandya P, Cantelli G, Boehme L, Wallberg F, V Tape C, Karagiannis SN, Malanchi I, Sanz-Moreno V (2020) Myosin II reactivation and Cytoskeletal remodelling as a hallmark and a vulnerability in melanoma resistance.
Cancer Cell, 37, 85-103. https://doi.org/10.1016/j.ccell.2019.12.003

Samain R and SanzMoreno V (2020) Cancer‐associated fibroblasts: activin A adds another string to their bow
Embo Molecular Medicine https://doi.org/10.15252/emmm.202012102

Orgaz JL and Sanz-Moreno V (2020). What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
Molecular & Cellular Oncology https://doi.org/10.1080/23723556.2020.1735911


-Foxall E, Staszowska A, Hirvonen L, Georgouli M, Ciccioli MC, Rimmer A, Calle Y, Sanz-Moreno V, Cox S. Jones GE, Wells CM (2019) PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells.
Cell Reports https://doi.org/10.1016/j.celrep.2019.11.016

-Maiques O, Georgouli M, Sanz-Moreno V (2019) Recent advances in tissue imaging for cancer research. F1000 Research https://f1000research.com/articles/8-1980/v1

-Rosel D, Fernandes M, Sanz-Moreno V and Brábek J (2019) Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis? Trends in Cancer

-Valcarcel-Jimenez L, Macchia A, Crosas-Molist E, Schaub-Clerigué A, Camacho L, Martín-Martín N, Cicogna P, Viera-Bardón C, Fernández-Ruiz S, Rodriguez-Hernandez I, Hermanova I, Astobiza I, Cortazar AR, Corres-Mendizabal J, Gomez-Muñoz A, Sanz-Moreno V, Torrano V, Carracedo A. (2019) PGC1α suppresses prostate cancer cell invasion through ERRα transcriptional control. Cancer Res. doi: 10.1158/0008-5472

-López-Luque J, Bertran E, Crosas-Molist E, Maiques O, Caballero-Díaz D, Malfettone A, Caja L, Addante A, Sánchez A, Herrera B, Serrano T, Ramos E, Sanz-Moreno V* &, Fabregat I* (2019). Loss of EGFR in hepatocellular carcinoma facilitates TGF-β induced epithelial to amoeboid transition.Cancer Lett 464:15-24. doi:10.1016/j.canlet.2019.08.011. *co-senior authors.

-Dukinfield M, Maniati E, Reynolds L, Aubdool A, Baliga R, D'Amico G, Maiques O, Wang J, Bedi K, Margulies K,Sanz-Moreno V, Hobbs A, Hodivala-Dilke K. Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease.Journal of Pathology. doi: 10.1002/path.5340.

-Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Cantelli G, Rodriguez-Hernandez I, Karagiannis P, Lam H, Josephs D, Matias-Guiu X, Marti RM, Nestle FO, Orgaz JL, Malanchi I, Fruhwirth GO, Karagiannis SN and Sanz-Moreno V (2019) Regional activation of Myosin II in cancer cells drives tumour progression via a secretory cross-talk with the immune microenvironment. Cell. Published: January 31, 2019. DOI: https://doi.org/10.1016/j.cell.2018.12.038


-Sanz-Moreno V and Balkwill FR (2018) Mets and NETs: The Awakening Force. Immunity. 49(5):798-800. doi: 10.1016/j.immuni.2018.11.009.

-Muliaditan T, Okesola M, Caron J, Georgouli M, Gordon P, Lall S, Kuzeva D, Pedro L, Shields J, Gillettn C, Diebold S, Sanz-Moreno V, Ng T, Hoste E, Arnold J (2018) Tumour-associated macrophages exploit an innate wound healing response to facilitate metastasis. Nat Comm. 9(1):2951. doi: 10.1038/s41467-018-05346-7.

-Victoria Sanz-Moreno. People and ideas (2018) J Cell Biol. http://doi.org/10.1083/jcb.201805043

-Villaronga MA, Hermida-Prado F, Granda-Díaz R, Menéndez ST, Álvarez-Teijeiro S, Quer M, Vilaseca I, Allonca E, Garzón E, Sanz-Moreno V, Astudillo A, Rodrigo JP, García-Pedrero JM. (2018) Immunohistochemical expression of cortactin and focal adhesion kinase predicts recurrence risk and laryngeal cancer risk beyond histological grading. In press, Cancer Epidemiology, Biomarkers & Prevention. doi: 10.1158/1055-9965.EPI-17-1082

-Maiques O, Barceló C, Panosa A, Pijuan J, Orgaz JL, Rodriguez-Hernandez I, Matas C, Vilella R, Fabra A, Puig S, Sanz-Moreno V, Matias-Guiu X, Canti C, Herreros J, Marti RM, Macià A (2018) T-type calcium channel blockers inhibit autophagy and reduce migration/invasion in BRAFV600E melanoma cells through Snail1 expression.Pigment Cell and Melanoma Res. doi: 10.1111/pcmr.12690.

-Villaronga MÁ, Teijeiro SÁ, Hermida-Prado F, Garzón-Arango M, Sanz-Moreno V, García-Pedrero JM. (2018) Analysis of Invasive Activity of CAF Spheroids into Three-Dimensional (3D) Collagen Matrices. Methods Mol Biol; 1731:145-154. doi: 10.1007/978-1-4939-7595-2_14.


-Pandya P, Orgaz JL and Sanz-Moreno V (2017)
Actomyosin contractility in collective migration: May the force be with you. Special issue on "Cell Dynamics”
Curr Opin Cell Biol, 48:87–96

-Gandalovičová A, Rosel D, Fernandes M, Veselý P, Heneberg P, Čermák V, Petruželka L, Kumar S, Sanz-Moreno V *and Brábek J* (2017) *co-corresponding authors MIGRASTATICS, the anti-metastatic and anti-invasion drugs: the promise and challenges. Trends in Cancer,3(6):391-406

-Orgaz and Sanz-Moreno V (2017)
IBook Chapter on RhoA. Encyclopedia of Signaling Molecules. Springer. DOI10.1007/978-1- 4614-6438-9_101793-1

-Victoria Sanz-Moreno: Cell scientist to watch. (2017) Featured J Cell Sci. 130(7):1199-1200

-Orgaz JL, Pandya P and Sanz-Moreno V (2017)
Modes of cell migration during cancer invasion and metastasis. In press, Molecular Oncology. 10.1002/1878-0261.12019.

-Krupina K, Kleiss C, Rodriguez-Hernandez I, Sanz-Moreno V and Sumara I (2017).
UBASH3B-mediated silencing of the mitotic checkpoint: therapeutic perspectives in cancer cells. Molecular & Cellular Oncology, 10.1080/23723556.2016.1271494

-Josephs D, Bax H , Dodev T , Georgouli M, Nakamura M, Pellizzari G, Saul L , Karagiannis P , Cheung A, Herraiz C, Ilieva K, Correa I, Fittall M, Crescioli S, Gazinska P, Woodman N, Mele S , Chiaruttini G, Gilbert A, Dr. Koers A, Bracher M, Selkirk C, Lentfer H, Barton C, Lever E, Muirhead G, Tsoka S, Canevari S, Figini M, Montes A, Downes N, Dombrowicz D, Corrigan C,. Beavil AJ, Nestle FO, Jones p, Gould H, Sanz-Moreno V, Blower P, Spicer J, Karagiannis S (2017)
IgE cancer immunotherapy is mediated by macrophage polarization via a TNFα/MCP-1 axis.
Cancer Res. doi: 10.1158/0008-5472.

-Crosas E, Bertran E, Cantelli G, Herraiz C, Rodriguez-Hernandez I, Fabra A, Sanz-Moreno V* and Fabregat I* (2017) *co-corresponding senior authors
NADPH oxidase 4 represses Epithelial to Amoeboid transition and efficient tumour dissemination. Oncogene. doi: 10.1038/onc.2016.454






get in touch

+ 44 (0) 7725112986

where to find us

Barts Cancer Institute- a Cancer Research UK Centre of Excellence
Queen Mary University of London, John Vane Science Building
Charterhouse Square, London EC1M 6BQ

about the lab

The Sanz-Moreno lab works on understanding how the cytoskeleton and Rho GTPase signalling in cancer cells promotes tumour growth and dissemination.