The Sanz-Moreno lab works on understanding how the cytoskeleton and Rho GTPase signalling in cancer cells promotes tumour growth and dissemination. We are interested in better defining how Rho GTPase signals are translated via transcription factors into appropriate pro-tumorigenic responses.

The lab combines 'OMICs', state of the art microscopy in 3D matrices, molecular biology, animal models and patient information to identify molecular determinants driven by Rho GTPase signalling that correlate with cancer progression and metastatic potential. Furthermore, we are very focused on characterising how the cytoskeleton in cancer cells controls tumour-stromal interactions.